The MRC/BHF CoRE in Advanced Cardiac Therapies (REACT) unites academic, healthcare, industry and public partners to develop innovative DNA and RNA-based therapies to regenerate injured hearts and reverse established damage.
Heart failure affects almost one million people in the UK and more than 65 million people around the world, with heart attacks the main cause. No current treatment is able to regenerate the heart after a heart attack.
Our growing community brings together scientists and clinicians across academia and industry to discover new medicines based on the fundamental processes that drive heart failure and regulate cardiac regeneration.
We are developing advanced cardiac therapies: first-in-human DNA and RNA-based medicines to rebuild injured hearts and improve heart function.
Projects addressing our three research challenges will accelerate our ability to identify therapeutic targets, deliver them successfully to the heart, and translate treatments from bench to bedside within the next decade.
Our approach
We are building a network of leading researchers and a positive, collaborative environment across all of our partner organisations.
This will provide a strong foundation for team science, training and career development, and open and engaged research.
The concept behind our centre
Our Directors have written about the evolution of our centre in an open-access CardioPulse article for the European Society of Cardiology.
Featured news and updates
Meet our leadership team
Opportunities to get involved
REACT is a virtual centre across the UK and beyond. Our mission is deeply collaborative and there are a range of ways for you to work, learn and partner with our specialists.
Help us embed lived experience in our work
We want to work more with patients and communities with experience of heart attack and failure. We are committed to listening to the views of those who stand to benefit from our therapies and shaping research together.
Updates direct to your inbox
Our termly newsletter is the place for curated news, events and opportunities from people and projects across REACT.